medRxiv PreprintsInternational5 October 2026
Safety & Effectiveness of Mifepristone for Medication Abortion in a National Claims Cohort, 2017-2023
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BACKGROUND Extensive research has documented medication abortion safety. Large-scale insurance claims data offer an important complement to clinical studies by assessing real-world outcomes in routine practice. In claims data, researchers must infer mifepristone use, clinical outcomes, and event severity from diagnosis, treatment, and utilization codes. Understanding how these analytic choices influence safety and effectiveness estimates is important for interpreting evidence used to inform care delivery and medication policy. METHODS We conducted a retrospective cohort study of mifepristone u
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