medRxiv PreprintsInternational16 October 2026
Remission of Type 2 Diabetes in Linked Health Records: Uncommon, Short-Lived, and More Often Ended by Treatment Restart Than by Rising HbA1c
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Objective: To estimate how often remission of type 2 diabetes is recorded in routine care, how long it lasts, and what ends it, separating a return of hyperglycemia from a restart of treatment. Research design and methods: We studied 136,781 adults aged 18 years or older with laboratory confirmed type 2 diabetes in the Protege linked electronic health record (EHR) and claims database. The 96,817 adults with glucose-lowering treatment recorded at or before cohort entry formed the primary (previously treated) cohort; 39,964 adults with no treatment recorded at entry were analyzed in parallel. Re
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