Pyelonephritis is associated with persistent alterations in immune-stromal and vascular programs in the human placenta

Maternal systemic infection during pregnancy is associated with placental dysfunction even when pathogens do not directly invade the placenta, but the cellular pathways linking antecedent infection to persistent placental alterations remain poorly defined. Here we used spatial transcriptomics to resolve trophoblast-, fetal endothelial, and Hofbauer cell-enriched niches in placentas collected at term after clinical recovery from antepartum pyelonephritis. We profiled 168 spatially defined areas from 14 placentas and integrated transcriptional findings with blinded histopathology and quantitativ

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