Potential effect of replacing sedentary behavior with physical activity on the risk of atrial fibrillation: results from the UK Biobank and REGARDS study

Background Sedentary behavior (SB) has been associated with cardiovascular disease risk, independent of physical activity (PA) and sleep. However, the effect of replacing SB with PA or sleep on atrial fibrillation (AF) risk remains unclear. Methods We studied 86,096 participants from the United Kingdom Biobank (UKB) and 5,777 from the United States (US) REasons for Geographic And Racial Differences in Stroke (REGARDS) prospective cohort studies who were free of AF at baseline and had valid accelerometry data. The two cohorts were included to evaluate the consistency of associations across dist

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