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medRxiv PreprintsInternational5 October 2026

Patterns of substance use during pregnancy are differentially associated with maternal mental health across the perinatal period

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Background: Substance use during pregnancy can substantially increase risk for postpartum depression and anxiety symptoms, which can have lasting effects on family functioning and child development. However, substance use is often conceptualized as a binary exposure, limiting our understanding of whether specific patterns of use are associated with maternal mental health in the perinatal period. Here, we examined longitudinal patterns of prenatal alcohol use and smoking in relation to maternal depressive and anxiety symptoms across pregnancy and the first two years postpartum. Methods: We anal
— medRxiv Preprints
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