Multi-centre validation of MELD-graph for automated focal cortical dysplasia detection using 7T compared to paired 3T MRI

Background: Software tools can support MRI diagnosis of focal cortical dysplasias (FCDs) - subtle, surgically-treatable lesions that underlie drug-resistant focal epilepsy (DRFE). MELD-graph, a widely used open-source tool combining surface-based morphometry with a convolutional neural network, was developed using 1.5T and 3T MRI data. 7T MRI is increasingly used for lesion detection in DRFE. This study investigated whether MELD-graph is robust to domain shift at 7T. Methods: We collated paired 3T and 7T T1-weighted MRI, and FLAIR where available, from 23 patients with FCD (6 histologically-ve

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