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medRxiv PreprintsInternational7 October 2026

Longitudinal trajectories of ADHD symptoms: relationships to early-childhood predictors and later outcomes

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Background: ADHD symptoms follow heterogeneous trajectories across childhood and adolescence, with important implications for later functioning. Early-life factors, including perinatal health, family environment, cognition, socioeconomic conditions, and community exposures, may contribute to this variability. The present study examined (1) early-life predictors of ADHD symptom trajectories, and (2) ADHD symptom trajectories as predictors of later substance use, suicidality, and new-onset psychiatric disorders. Methods: Growth models were used to fit longitudinal trajectories of inattention, hy
— medRxiv Preprints
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