Longitudinal multi-omic profiling separates persistent from resolving sequelae of breast cancer treatment

Long-term treatment sequelae shape health and quality of life for years after breast cancer, yet why some women develop them and others recover remains unclear. Here we follow 16 women through chemotherapy and for two years afterwards, with patient-reported symptoms, clinical chemistries, plasma proteomics, metabolomics, and gut microbiome profiles collected across eight visits from a pre-treatment baseline. Sequelae differ in their timing, with some resolving as chemotherapy ends, whereas fatigue, memory problems, and gas bloating can persist, and weight gain and joint pain can appear only af

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