Latent Genetic Factors and Causal Pathways Linking Substance Use to Psychiatric and Personality Phenotypes: a Genomic SEM and Mendelian Randomization Study

Substance use and psychiatric disorders frequently co-occur, but establishing causality of their relationships is difficult given the multifactorial nature of these traits. To assess these relationships, we applied two genetically informed methods using the largest available European-ancestry genome-wide association studies of six substance use behaviors and twelve psychiatric and personality phenotypes. Using Genomic Structural Equation Modelling, we modelled the latent genetic architecture of the psychiatric and personality traits and examined these factors' correlations with substance use t

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