Functional organization of multimorbidity links chronic disease incidence to shared genetic architecture

The multistage model of carcinogenesis explains the steep rise of cancer incidence with age through accumulated events, and reliability theory extends this principle to systems whose failure requires several components. We asked whether the same idea could explain why chronic diseases differ in how rapidly incidence rises with age, and whether multimorbidity could independently reveal the processes involved. In UK Biobank, linked health records allowed pre-assessment disease co-occurrence and subsequent incidence to be analysed separately. Using generative representation learning, we derived f

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