Evidence synthesis on sex differences in mortality after traumatic brain injury: Systematic review integrating meta-analysis and explainable machine learning

Sex differences in mortality after traumatic brain injury (TBI) have been inconsistently reported, even after accounting for age, injury severity, and other injury related factors. Understanding the sources of this heterogeneity is important for prognostic research and the development of data-driven clinical decision-support tools. We conducted a systematic review and meta-analysis of sex-specific mortality after adult TBI and used explainable machine learning (ML) to investigate potential modifiers of between-study effect estimates. We searched eight databases from inception to August 25, 202

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