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medRxiv PreprintsInternational5 October 2026

Does chronotype influence the odds of diabetes comorbidity in bipolar disorder? A cross-sectional analysis of the Our Future Health cohort.

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Background Diabetes is common in people with bipolar disorder, particularly men. Both type 2 diabetes and bipolar disorder are associated with evening chronotype, and men of working-age have later chronotypes than women. However, it is not known whether elevated rates of diabetes in bipolar are explained by evening chronotype, nor whether sex differences in chronotype contribute to higher rates of diabetes observed in men with bipolar disorder. Aim To determine whether evening chronotype increases the likelihood of comorbid type 2 diabetes in bipolar disorder, relative to those with no mental
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