A Digital Environment for Multi-modal Relational Management, Representation, and Analysis of Cancer Clinical Studies

Biologically rich clinical trials generate heterogeneous datasets whose relationships and clinical context must be preserved. Here we present the POETIC-AI environment, a trial-centric digital environment for integrating, analysing, and exploring multimodal data from POETIC, a randomised phase III trial of peri-operative aromatase inhibition in hormone receptor-positive breast cancer (NCT02338310). We implemented a graph-based ontology linking patients, treatments, sampling timepoints, specimens, assays, images, spatial regions, and derived measurements; and designed code-based and graphical a

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