TrialCalibre1: An Agentic System for Trial Emulation, Benchmarking, and Calibration

TrialCalibre1 is an agentic system that connects clinical evidence, study design, and executable analyses. It supports reference-trial replication, direct target-trial emulation, and BenchExCal, which combines benchmarking, extension, and cal ibration sensitivity analysis. We evaluated an ASCET-based benchmark and an extension comparing clopidogrel with aspirin among adults aged 81-90 years us ing synthetic PCORnet-style claims. Two reviewers assessed benchmark extrac tion, protocol decisions, and implementation. After discussion, 53/62 and 50/62 assessable SQL checks were rated met; both revi

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