REM sleep EEG slowing signals basal forebrain integrity in older adults with subjective and mild cognitive impairment

Introduction The basal forebrain is an early site of pathology in Alzheimer's disease (AD). Within this region, the nucleus basalis of Meynert (NbM) provides the primary cholinergic input to the neocortex and supports cortical activation during rapid eye movement (REM) sleep. REM electroencephalography (EEG) slowing is observed in older adults with AD and amnestic mild cognitive impairment (MCI). This study examined the relationship between REM EEG slowing and NbM volume, and whether it differed by cognitive status, sex, or sleep apnea severity. Methods Participants aged [≤] 60 years with c

This content is for informational purposes only and is not medical advice. It is not intended to diagnose, treat, cure, or prevent any disease. Consult a healthcare professional before starting any supplement, treatment, or program — especially if you are pregnant, nursing, taking medication, or managing a health condition.