Rapid Molecular Assessment of Kidney Allograft Rejection Using the Biopsy Transport Medium

Introduction Timely diagnosis of kidney allograft rejection is critical for post-transplant management, yet treatment decisions may need to be made empirically while awaiting the final pathology report. We previously demonstrated that biopsy transport medium (BTM) contains molecular signals reflective of allograft rejection. Building on these findings, we developed a rapid BTM qPCR workflow using a targeted gene panel for early molecular assessment of rejection. Methods Kidney transplant biopsies assessed at Leiden University Medical Center from April 2023 to November 2024 were eligible. A pre

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