Psychotropic Receptor Modulation and Cognition in Psychotic Disorders

Background: Cognitive impairment is a major determinant of functional outcome in psychotic disorders, yet the contribution of psychotropic medication is incompletely understood. This study aimed to determine whether personalised receptor-engagement profiles derived from prescribed psychotropic medications are associated with cognitive performance in individuals with psychotic disorders. Methods: We performed a cross-sectional study using clinical, cognitive, and medication data from the Bipolar-Schizophrenia Network on Intermediate Phenotypes studies. In 1,067 (51.5% female) individuals with p

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