Population-scale trends and variations in human aortic biomechanics

The biomechanical properties of the human aorta play a key role in cardiovascular function and disease, yet their population-wide trends and variations remain largely unknown. To fill this crucial gap, we quantified variations in aortic size, stiffness and stresses across 57,434 individuals from the UK Biobank using two-dimensional cine MR imaging and a combined deep-learning, probabilistic and biomechanical modelling framework. Aortic diameter and distensibility (inverse of stiffness) were calculated for the ascending and descending aorta, and their conditional distributions were characterise

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