Physical Activity Initiation and Incident Mobility Difficulty Among Older Adults: A Sequential Target Trial Emulation

Although physical activity is associated with better physical functioning, the effects of initiating regular physical activity among older adults with persistent inactivity remain unclear. We conducted a sequential target trial emulation using Health and Retirement Study (HRS) data to estimate the effect of physical activity initiation versus noninitiation on incident mobility difficulty. Participants were included in the analysis if they were aged [≥]65 years at the previous wave, reported no regular physical activity at the previous two waves, and had no mobility, activities of daily livi

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