medRxiv PreprintsInternational14 October 2026
Multi-omics proposes a complement-adhesion-stromal-vascular (CASVR) framework in chronic rhinosinusitis with nasal polyps
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Type 2 inflammation is central to chronic rhinosinusitis with nasal polyps (CRSwNP), but it does not fully explain persistent stromal and vascular remodeling. We asked whether complement, adhesion, stromal, and vascular signals converge across tissue, cellular, and spatial scales. We integrated four bulk-transcriptomic cohorts with a single-cell atlas and GeoMx spatial transcriptomics. Network analysis identified eight contrast-associated hub genes and an ABCC9-ACTA2-GPM6A score that separated study-defined groups across cohorts. Single-cell mapping localized these genes mainly to pericytes, f
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