Methylation-defined tumour subgroups guide recognition of genetic predisposition in Wilms tumour

Up to one-third of Wilms tumours (WTs) arise in the context of genetic or epigenetic predisposition, but identifying predisposed patients remains challenging because germline variants can be missed due to variable clinical presentation, mosaicism, and cryptic variants. We tested whether tumour-derived molecular patterns can reveal underlying predisposition and thereby complement conventional diagnostic approaches. DNA methylation profiling of 138 WTs identified five molecular clusters that captured biological and predisposition-associated heterogeneity, including enrichment for Beckwith-Wiedem

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