Location-specific Longitudinal Patterns of Subcortical and Lobar Cerebral Microhemorrhages in Preclinical Alzheimer Disease

Abstract Background and Objectives Cerebral microhaemorrhages influence eligibility and monitoring for anti-amyloid therapies. Emerging evidence and expert opinion suggest that subcortical microhaemorrhages may be less closely related to cerebral amyloidosis than lobar lesions and may therefore warrant separate consideration in anti-amyloid treatment eligibility criteria. Using longitudinal MRI data from cognitively unimpaired individuals with preclinical Alzheimer disease in the A4 study, we hypothesised that lobar and subcortical microhaemorrhages would show distinct location-specific patter

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