Limited incremental value of three complete-blood-count inflammatory indices for cardiovascular mortality: a development and external validation study in 30,533 US adults

Abstract Routine blood tests can be used to calculate several inflammation-related ratios, including the neutrophil-to-lymphocyte ratio (NLR), systemic immune-inflammation index (SII), and platelet-to-lymphocyte ratio (PLR). These indices are widely reported as markers of cardiovascular risk, but it is unclear whether they provide comparable information or whether SII, which is derived from platelet count and NLR, adds anything beyond NLR. We analyzed two independent samples from the National Health and Nutrition Examination Survey (NHANES): 15,141 adults from 2005-2010 (development cohort) an

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