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medRxiv PreprintsInternational1 October 2026

Impact of Daily Physical Fatigue on Inter-Limb Load Asymmetry and Joint Loading Rates During Daily Living Tasks in Unilateral Knee Osteoarthritis

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Background: Knee osteoarthritis (OA) is characterized by progressive joint degradation and altered gait biomechanics. Inter-limb load asymmetry during daily living tasks may accelerate joint deterioration, particularly when combined with physical fatigue. This study investigates the relationship between daily physical fatigue and inter-limb load asymmetry patterns during functional activities in individuals with unilateral knee OA. Objective: To evaluate the impact of fatigue on inter-limb load asymmetry and joint loading rates during daily living tasks in patients with unilateral knee osteoar
— medRxiv Preprints
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