medRxiv PreprintsInternational13 October 2026
Ex-vivo 7T MRI for accurate margin assessment in oral squamous cell carcinoma surgery
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Introduction: Resection margins in oral squamous cell carcinoma (OSCC) are frequently inadequate. This study investigated the accuracy and diagnostic performance of ex-vivo 7T MRI against histology. Methods: Fifty OSCC specimens underwent ex-vivo 7T MRI. Tumours were segmented on corresponding histology and twice on MRI: blinded to histology (radiologist segmentation; clinical practice) and using histology (histology-MR segmentation; MR-based ground truth). Resection margins were measured in five regions and compared with histology. Results: Anterior and posterior margins were generally smalle
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