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medRxiv PreprintsInternational14 October 2026

Daily personalized music listening versus audiobook listening for chronic non-cancer pain in patients on long-term opioid therapy: a randomized controlled trial

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Non-pharmacological adjuncts are needed for chronic non-cancer pain in patients receiving long-term opioid therapy. Music listening may reduce pain, but most previous trials have used passive controls, limiting attribution of effects specifically to music. In this open-label, parallel- group, proof-of-concept randomized controlled trial, adults with chronic non-cancer pain receiving long-term opioid therapy were randomized 1:1 to four weeks of daily home-based music or audiobook listening. Analgesic outcomes included pain intensity, responder rates, quantity of pain relief, and multidimensiona
— medRxiv Preprints
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